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CTMR/BioCAT collaboration leads to new PNAS paper “Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force“ The UW Center for Translational Muscle Research (CTMR) working with the Regnier Lab and the BioCAT x-ray beamline at the Advanced Photon Source of Argonne National Lab, explore the potential of sarcomere-targeted small molecules as treatments…

2022 Myofilament Meeting
In May, CTMR Investigators participated in the 2022 Myofilament research conference “Myofilament Form and Function: Determinants of Sarcomeric Contractility” in Madison, Wisconsin.

Work Presented at the Biophysical Society Annual Meeting
Research work funded in part by the UW Center for Translational Muscle Research (CTMR) was recently presented at the 66th Biophysical Society Annual Meeting in San Francisco, CA. Congratulations to all presenters!
2022 UW CTMR ANNUAL SYMPOSIUM
Save the Date! The 2022 UW CTMR Symposium will be held on Monday, October 24th, 2022 from 9:00am – 6:00pm Pacific Time in the Orin Smith Auditorium. Registration information and additional details coming soon.

Congratulations to CTMR Team Core D for their JGP May cover showing “A detailed computational model of striated muscle elucidates how mutations and drugs may alter twitch timing. The spatially explicit model simulates myosin motors connected within a compliant, contractile lattice, complete with thin filament regulation and varying mutation penetrance. The model yields data used…