Molecular model of myosin.

New Grants Power Muscle Science

Two new grants will accelerate atomic-scale research into the molecular mechanisms of cardiomyopathies. In Autumn 2024, CTMR investigator Matthew Childers was awarded a competitive K99/R00 Pathway to Independence Award from the National Heart, Lung, and Blood Institute of the NIH. Childers’ project combines computational simulations of muscle proteins with stem-cell derived cardiomyocytes to create a…

Complex problems require collaborative science

Complex problems require collaborative science

CTMR Investigators, Mike Regnier and David Mack, were part of a multi-institutional research effort to uncover the disease mechanism for hypertrophic cardiomyopathy caused by a mutation in myosin (MYH7 G256E). The project was a collaborative effort between investigators at UW, Stanford University, University of California Santa Barbara, the Curie Institute in Paris, and the Allen Institute for Cell…

Congratulations to Alec Smith!

Congratulations to Alec Smith!

CTMR Investigator Alec Smith, PhD, recently had an R21 funded through the NIAMS that will be looking at developing human stem cell-based models of the muscle spindle for studying proprioceptive function in skeletal muscle. Additionally, he received an Award from the Weill Neurohub to develop models of the neuromuscular junction for studying amyotrophic lateral sclerosis…