2022 Myofilament Meeting

Byctmr1 June 23, 2022June 23, 2022

In May, CTMR Investigators participated in the 2022 Myofilament research conference “Myofilament Form and Function: Determinants of Sarcomeric Contractility” in Madison, Wisconsin.

Saffie Mohran presented “Embryonic myosin mutations T178I & R672C result in mechanical and structural dysfunction in hPSC derived skeletal muscle”.

Farid Mousseri-Harami presented “Dancamtiv reversed negative effects on cardiac myofilament function in the I61Q cTnC mouse model of dilated cardiomyopathy”.

Bykd February 6, 2023February 6, 2023

CTMR/BioCAT collaboration leads to new PNAS paper “Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force“ The UW Center for Translational Muscle Research (CTMR) working with the Regnier Lab and the BioCAT x-ray beamline at the Advanced Photon Source of Argonne National Lab, explore the potential of sarcomere-targeted small molecules as treatments…

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Congratulations to CTMR Team Core D for their JGP May cover
Bykd June 15, 2023April 20, 2026

Congratulations to CTMR Team Core D for their JGP May cover showing “A detailed computational model of striated muscle elucidates how mutations and drugs may alter twitch timing. The spatially explicit model simulates myosin motors connected within a compliant, contractile lattice, complete with thin filament regulation and varying mutation penetrance. The model yields data used…

Read More Congratulations to CTMR Team Core D for their JGP May cover
CTMR sponsors Biophysical Society Thematic Meeting July 2023
Bykd August 15, 2023August 15, 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation thematic meeting, which was held in Canterbury, England on July 17-20, 2023. CTMR invited speakers included: Several CTMR graduate students and postdocs presented posters as well.

Read More CTMR sponsors Biophysical Society Thematic Meeting July 2023
CTMR represents at the 50th European Muscle Conference Florence 2023
Bykd August 15, 2023August 15, 2023

Dr. Mike Regnier is an invited speaker at the 50th European Muscle Conference (EMC) coming up in September 2023. The EMC will be in held in Florence, Italy. Dr. Regnier will be the “DISEASE MODELS” session chair and his talk title will be: “Molecular mechanisms of contractile abnormalities for the MYH7 variant G256E”. Graduate student,…

Read More CTMR represents at the 50th European Muscle Conference Florence 2023
Dr. Nagana Gowda’s CTMR Pilot Project leads to R01 Grant Award
Byctmr1 July 15, 2021November 21, 2024

Dr. Nagana Gowda, CTMR Investigator and Research Associate Professor in the Department of Anesthesiology & Pain Medicine, has been awarded an NIH Research Project Grant (R01) thanks in part to CTMR Pilot Grant support. Dr. Gowda’s awarded project is entitled “Quantitative Analysis of Labile Metabolites in Biological Samples” and focuses on addressing the current lack…

Read More Dr. Nagana Gowda’s CTMR Pilot Project leads to R01 Grant Award
Dr. Ru Gunawardane joins CTMR External Advisory Board
Byctmr1 July 15, 2021April 20, 2026

We are excited to announce that Ruwanthi (Ru) Gunawardane, Ph.D. is joining CTMR as a member of our External Advisory Board. Ru was recently named Executive Director of the Allen Institute for Cell Science in 2020 after spending five years at Amgen, where she worked on assay development for multiple drug targets spanning oncology, inflammation,…

Read More Dr. Ru Gunawardane joins CTMR External Advisory Board

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